Progressive Multifocal Leukoencephalopathy with Wallerian Degeneration
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چکیده
منابع مشابه
Progressive multifocal leukoencephalopathy with wallerian degeneration.
A 39-year-old male presented with slurred speech, left hand weakness, gait unsteadiness and headaches over a period of 4 weeks. A brain MRI revealed a right motor strip lesion with Wallerian degeneration along the pyramidal tract plus brain stem and cerebellar FLAIR changes without enhancement ( fig. 1 ). Laboratory findings included a CD4 count of 56, HIV viral load of 2,597 and a positive CSF...
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Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...
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Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts. Once reactivated, JCV infects oligodendrocytes and a...
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Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John C...
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Treatment of progressive multifocal leukoencephalopathy (PML) in a patient with exogenous immunosuppression starts with discontinuation of immunosuppressive medication. The restored host immunity will clear JC virus, the cause of PML, from the brain via cell-mediated immune mechanisms. Patients with solid-organ transplants will lose the transplanted organ, however, and patients who have autoimm...
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ژورنال
عنوان ژورنال: European Neurology
سال: 2011
ISSN: 1421-9913,0014-3022
DOI: 10.1159/000331770